Mass Spectrometry Labs
The laboratory is equipped with a series of user-friendly state-of-the-art mass spectrometers in different hardware configurations. The lab enables qualitative and quantitative analysis services, development of methods as well as new applications designed to meet the rapidly evolving needs in the field. The facility offers routine mass spec services, molecular weight determination, MSn, LC-MS, high resolution MS, and database search.
SCION TQ GC-MS System (Bruker)
System with a triple quadrupole detector is a comprehensive solution for most demanding gas chromatography applications. This GC-MS system is designed to analyze samples from even the dirtiest matrices such as sewer run-off, food homogenates, oil field sludge, whole blood and tissue.
Impact HD ESI-Q-TOF mass spectrometer (Bruker)
Impact HD is a Hybrid Quadrupole/Atmospheric Pressure Ionization orthogonal accelerated Time-Of-Flight mass spectrometer. This equipment sets the standard in ultra-high-resolution tandem mass spectrometry across a wide range of analytical applications. It ensures intact protein analysis and characterization of bio-pharmaceuticals, synthetic chemistry support, forensics and doping control, food products and many more. Samples can be introduced into API-electrospray ionization by syringe pump or liquid chromatographic system. The combination of LC (UltiMate 3000 LC System UHPLC+ Focused (Thermo Scientific/Dionex)) and MS allows detection of masses in complex matrices.
The LC system is routinely run in connection with a high-resolution MS spectrometer, however, it is also equipped with its own, fast (200 Hz) diode-array detector.
NexION 300D ICP-MS spectrometers (Inductively Coupled Plasma Mass Spectrometer) (PerkinElmer Inc.)
The system is capable of detecting metals and several non-metals a t c oncentrations a s low a s one part in 1012. The technique offers great speed, precision, and sensitivity and can be used for both qualitative and quantitative approaches. Possible applications are in medical and forensic field, toxicology, industrial and biological monitoring (metal analysis), radiometric dating, and more.
AB Sciex QTRAP 6500 System SelexION coupled with an Eksigent LC100 UHPLC system
The system is a triple quadrupole mass spectrometer with a linear ion trap technology. It is designed for quantitative analysis featuring scan speeds of up to 20,000 Da/s for optimized UHPLC measurements and a mass range of up to 2000 m/z upper mass limit. Additional unique features of the system include: MRM3 workflows, peptide quantitation, targeted trace analysis of contaminants as well as great confidence in forensic toxicology applications. It is also equipped with a unique SelexION Differential Ion Mobility Technology designed for elimination of challenging co-eluting contaminants, and reduction of high background noise.
AB Sciex QTOF 5600+ coupled with Eksigent LC200 micro LC system
This Triple TOF System (AB Sciex) is a high-resolution quadrupole TOF technology mass spectrometer.
It integrates comprehensive, qualitative exploration, rapid profiling, and high-resolution quantitation workflows. Basic features: MS and MS/MS modes of operation, dual ESI/APCI ion source, 100 Hz acquisition speed, low limits of quantitation (LOQ) for a high-resolution system, direct infusion or LC sample introduction.
MALDI TOF/TOF UltraflexXtreme (Bruker)
The new mass spectrometer offers ultrahigh performance and flexibility for a broad variety of complementary research, clinical and applied proteomics applications. The system is
designed for high-throughput protein identification by MALDI-TOF peptide mass fingerprinting. The data can be readily searched through databases, allowing rapid identification of proteins, and further interpreted using the Biotools software suite. The system features up to 40,000 mass resolution and 1 ppm mass accuracy, high throughput analysis with
2 kHz laser and 384 well sample target. Possible applications include: routine peptide MW measurements, proteins up to 100 kDa, oligosaccharides, oligonucleotides, soluble proteins from microorganisms. Synthetic polymer analysis using Polytools Software and more advanced Polymerix software package (Sierra Analytics).
